Monitor Closely (one)mitotane decreases amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Mitotane can be a strong inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for doable dosage changes.Drugs which have step therapy linked to Each individual prescription. Thi